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Publication date: 2018-06-13 23:59

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VIAGRA may affect the way other medicines work, and other medicines may affect the way VIAGRA works causing side effects. Especially tell your healthcare provider if you take any of the following:

HIGHLIGHTS OF PRESCRIBING INFORMATION - Pfizer

The chambers also contain a network of blood vessels. When those blood vessels relax and widen, blood rushes in. The resulting pressure is what causes an erection.

Nitric Oxide for Working Stiffs – Say . to Erectile

There are no controlled clinical data on the safety or efficacy of VIAGRA in patients with retinitis pigmentosa (a minority of these patients have genetic disorders of retinal phosphodiesterases) if prescribed, this should be done with caution.

How does Viagra work? - | Prescription Drug

This Patient Information leaflet summarizes the most important information about Viagra. If you would like more information, talk with your healthcare provider. You can ask your healthcare provider or pharmacist for information about Viagra that is written for health professionals.

In fixed-dose studies, the incidence of some adverse reactions increased with dose. The type of adverse reactions in flexible-dose studies, which reflect the recommended dosage regimen, was similar to that for fixed-dose studies. At doses above the recommended dose range, adverse reactions were similar to those detailed in Table 6 below but generally were reported more frequently.

Within the penis are two chambers called the corpora cavernosa. Nitric oxide (NO) is released in the chambers during sexual stimulation. NO activates an enzyme called guanylate cyclase. That increases levels of cyclic guanosine monophosphate (cGMP), which causes muscles to relax.

The mean profiles of the change from baseline in standing systolic blood pressure in subjects treated with doxazosin in combination with 655 mg VIAGRA or matching placebo are shown in Figure 9.

Mean sildenafil plasma concentrations measured after the administration of a single oral dose of 655 mg to healthy male volunteers is depicted below:

After patients have taken VIAGRA, it is unknown when nitrates, if necessary, can be safely administered. Although plasma levels of sildenafil at 79 hours post dose are much lower than at peak concentration, it is unknown whether nitrates can be safely co-administered at this time point [see DOSAGE AND ADMINISTRATION , DRUG INTERACTIONS , and CLINICAL PHARMACOLOGY ].

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